Question: What parts of the genome are reversibly methylated?
Reversible DNA methylation occurs on cytosine residues within CpG dinucleotides in the genome, particularly in regions of DNA called CpG islands. CpG islands are typically found in promoter regions of genes and play a role in regulating gene expression. Methylation of CpG islands can silence gene expression by preventing the binding of transcription factors and other regulatory proteins. Demethylation, on the other hand, can activate gene expression. Reversible DNA methylation is an important mechanism of epigenetic regulation in development, cellular differentiation, and disease.
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