Suppose a mutation occurs in the gene for a particular aminoacyl-trna synthetase. the mutation changes which amino acid is recognized, without affecting which trna molecule is recognized. how is this likely to affect protein synthesis? Skip to main content

Suppose a mutation occurs in the gene for a particular aminoacyl-trna synthetase. the mutation changes which amino acid is recognized, without affecting which trna molecule is recognized. how is this likely to affect protein synthesis?

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Question: Suppose a mutation occurs in the gene for a particular aminoacyl-trna synthetase. the mutation changes which amino acid is recognized, without affecting which trna molecule is recognized. how is this likely to affect protein synthesis?

Aminoacyl-tRNA synthetases are enzymes that catalyze the attachment of specific amino acids to their corresponding tRNA molecules. Each aminoacyl-tRNA synthetase is specific to a particular amino acid and recognizes a specific tRNA molecule.


If a mutation occurs in the gene for a particular aminoacyl-tRNA synthetase that changes which amino acid is recognized without affecting which tRNA molecule is recognized, it could have significant consequences on protein synthesis.


For example, if the mutated aminoacyl-tRNA synthetase now recognizes a different amino acid, it may attach that amino acid to the tRNA molecule instead of the original amino acid. This would change the identity of the amino acid that is incorporated into the growing protein chain during translation. This, in turn, could alter the protein's structure and function, potentially leading to changes in cellular processes or even disease.


Furthermore, if the mutated aminoacyl-tRNA synthetase recognizes an amino acid that is normally not incorporated into proteins, this could lead to the production of abnormal or non-functional proteins, which can have a wide range of effects on cellular processes.


Overall, any mutation that alters the specificity of an aminoacyl-tRNA synthetase has the potential to significantly affect protein synthesis and, consequently, the function of the cell and organism.



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